Chlamydiae are sensitive to various antibiotics including tetracycline and erythromycin. Tetracyclines are also effective against mycoplasmal infections. No effective single dose treatment is available. Penicillins and other beta lactams are ineffective. Standard practice is to treat patients on the demonstration of cervicitis or urethritis or on the basis of a contact history.

Patients should avoid sexual intercourse until treatment is completed. The importance of compliance with treatment should be stressed.

The recommended treatment for NGU or NGC is a tetracycline (e.g. doxycycline 100 mg twice daily taken with food or milk for 10 days). Regimens for treatment of PID are detailed on pp. 14-15. The sequelae of these infections can be serious and treatment should not be delayed until laboratory investigations are complete.

Tetracyclines are contraindicated in pregnancy and children of 8 years of age or less.
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